International Case Studies

• MINHEE LEE et al.: Fish Collagen Peptide (NaticolⓇ): Protects the Skin from Dryness, Wrinkle Formation, and Melanogenesis Both In Vitro and In Vivo 2022
• FELICE V. D. et. al.: Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium. Nutrients. 2018 Jul; 10(7): 912.
• MAZAHERI NIA L. et. al.: Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial. J Sex Marital Ther. 2021;47(8):804-813.
• SHIN BC. et al.: Maca (L. meyenii) for improving sexual function: a systematic review. BMC Complement Altern Med 10, 44 (2010).
• DE SOUZA KZ et. al.: Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause. 2016.
• GOPAL SRIRAM et. al.: Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J ObstetGynaecol Res. 2021 Dec;47(12):4414-4425.
• OKAMURA SHINICHI et. al.: Pueraria mirifica phytoestrogens improve dyslipidemia in postmenopausal women probably by activating estrogen receptor subtypes. Tohoku J Exp Med. 2008 Dec;216(4):341-51.
• BRIESE VOLKER et. al.: Black cohosh with or without St. John's wort for symptom-specific climacteric treatment—Results of a large-scale, controlled, observational study. Volume 57, Issue 4, 20 August 2007.
• EUN YOUNG JUNG et al.: Low Dose Yeast Hydrolysate in Treatment of Obesity and Weight Loss. Prev Nutr Food Sci. 2017 Mar;22(1):45-49. doi: 10.3746/pnf.2017.22.1.45.
• EUN YOUNG JUNG et al.: Yeast hydrolysate can reduce body weight and abdominal fat accumulation in obese adults. Nutrition; 2014, 30:25-32.
• EUN YOUNG JUNG et al.: Effects of yeast hydrolysate on neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) immunoreactivity in rats. Phytother Res. 2009 May;23(5):619-23.
• HONG K et al.: Performance Enhancing Diets and the PRISE Protocol to Optimize Athletic Performance. Progr. Nutr.; 2015, 17:3:262-264.
• SCHUNCK M. et al.: Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology, J Med Food. 2015 Dec;18(12):1340-8.
• YAVARPOUR-BALI H. et al.: Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Int J Nanomedicine. 2019 Jun 17;14:4449-4460.
• VOLLONO L. et al.: Potential of Curcumin in Skin Disorders. Nutrients. 2019 Sep 10;11(9):2169.
• ZIA A. et al.: The role of curcumin in aging and senescence: Molecular mechanisms. Biomed Pharmacother. 2021 Feb;134:111119.
• YADAV R. et al.: Antibacterial and Antiinflammatory Properties of Bovine Colostrum. Recent Pat Inflamm Allergy Drug Discov., 2016;10(1):49-53.
• SATYARAJ E. et al.:: Supplementation of diets with bovine colostrum influences immune function in dogs. Br J Nutr. 2013 Dec;110(12):2216-21.
• YADAV r., et al.: Antibacterial and Antiinflammatory Properties of Bovine Colostrum, Recent Pat Inflamm Allergy Drug Discov. 2016;10(1):49-53.
• MENCHETTI L., et al.: Potential benefits of colostrum in gastrointestinal diseases, Front Biosci (Schol Ed). 2016 Jun 1;8(2):331-51.
• SANGILD P.T., et al.: Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health, Nutrients. 2021 Jul 26;13(8):2551.
• KELL D.B. et al.: The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria. Frontiers in immunology 2020
• LEPANTO M.S. et al.: Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-pregnant Women: An Interventional Study. Frontiers in immunology. 2018
• WOTRING J. W. et al.: Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern. Journal of Dairy Science. 2022
• SUN J. et al.: Bovine lactoferrin suppresses high-fat diet induced obesity and modulates gut microbiota in C57BL/6J mice. J Funct Foods. 2016
• TELANG S. et al.: Lactoferrin: A Critical Player in Neonatal Host Defense. Nutrients. 2018
• DELMAS D. et al.: New Highlights of Resveratrol: A Review of Properties against Ocular Diseases. International Journal of Molecular Sciences. 2021
• HARPER S.A. et al.: Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial. Experimental Gerontology. 2021
• WONG R.H. et al.: Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2020
• ZAW J.J.T. et al.: Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clinical Nutrition. 2021
• FLOROU P. et al.: Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials, J Assist Reprod Genet. 2020
• RAUCHOVÁ H. et al.: Coenzyme Q10 Effects in Neurological Diseases, Physiol Res. 2021
• Colostrum: Elixir of Life:
• The Clinical Research with AB-Fortis® Iron Supplements: The bioavailability of AB-Fortis® compared to uncoated ferrous sulphate was evaluated in a two-way, randomized, double-blind, cross-over postprandial intervention in healthy volunteers by measuring two iron blood parameters: transferrin saturation and total serum iron.
• VACLAV VETVICKA and JANA VETVICKOVA; Anti-infectious and Anti-tumor Activities of β-glucans:
• Vaclav Vetvicka: Comparison of immunological effects of commercially available β-glucans
• GUTIÉRREZ S. et al.: Effects of Omega-3 Fatty Acids on Immune Cells. International Journal of Molecular Sciences
• KELEI L. et al.: Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-Reactive Protein, Interleukin 6 and Tumor Necrosis Factor α: A Meta-Analysis. PLoS One. 2014
• KANG J. X. et al.: Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids. Lipids in Health and Disease. 2008
• ZHANG Y. et al.: Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. Journal of immunology. 2012.
• HOE E. et al.: Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection. Nutrients. 2016.
• QU H. et al.: Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.J Am Heart Assoc. 2018
• ZOZINA V. I. et al.: Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem. Curr Cardiol Rev. 2018
• KALT W. et al.: Recent Research on the Health Benefits of Blueberries and Their Anthocyanins.:Advances in Nutrition 2019
• WANG Y. et al: The protective effects of berry-derived anthocyanins against visible light-induced damage in human retinal pigment epithelial cells.:J Sci Food Agric. 2015
• BORISSENKO M.: Colostrum and the Performance Horse. 2002
• FENGER C. et al: Bovine colostrum supplementation optimises earnings, performance and recovery in racing Thoroughbreds.: Comparative Exercise Physiology 2014
• MBESE Z. et al.: Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers.: Molecules 2019
• ZHAO W. et al.: Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation.: J Biochem Mol Toxicol. 2018
• ROSSI A. et al.: Comparitive effectiveness of Finasteride vs Serenoa repens in male androgenetic alopecia: a two year study.: Int J Immunopathol Pharmacol. 2012
• ZHU H. L. et al.: Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial.
• YE Z. et al.: Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial.: Urology 2019
• SUDEEP H.V. et al.: A phytosterol-enriched saw palmetto supercritical CO2 extract ameliorates testosterone-induced benign prostatic hyperplasia by regulating the inflammatory and apoptotic proteins in a rat model.: BMC Complement Altern Med. 2019
• LEENTJENS J. et al.: The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study.: PLoS ONE 2014
• KIM H.S. et al.: Stimulatory Effect of β-glucans on Immune Cells.: Immune Netw 2011
• STIER H. et al.: Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan.: Nutr J 2018
• SINGHAL A. et al.: Dietary Nucleotides and Early Growth in Formula-Fed Infants: A Randomized Controlled Trial 2010
• WANG L. et al.: Effects of Nucleotides Supplementation of Infant Formulas on Plasma and Erythrocyte Fatty Acid Composition: A Meta-Analysis 2015
• ASTRUP A. et al.: Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990.
• ONAKPOYA I. et al.: Chromium supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. Obes Rev. 2013.
• HURSEL R. et al.: Catechin- and caffeine-rich teas for control of body weight in humans. Am J Clin Nutr. 2013.
• RAINS T.M. et al.: Antiobesity effects of green tea catechins: a mechanistic review. J Nutr Biochem. 2011.
• FOGACCI F. et al.: Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Crit. Rev. Food Sci. Nutr. 2018.
• LIU K. et al.: Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Am. J. Clin. Nutr. 2014.
• TURNER R.S. et al.: A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015.
• WITTE A.V. et al.: Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neurosci. 2014.
• MOBASHERI A. et al.: Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis. Ann NY Acad Sci. 2013.
• ORNSTRUP M.J. et al.: Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial. J. Clin. Endocrinol. Metab. 2014.
• POLUSEN M.M. et al.: Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men. J. Funct. Foods. 2014.
• SCHOLEY A. et al.: Anti-Stress Effects of Lemon Balm-Containing Foods. Nutrients. 2014.
• BUCHWALD-WERNER S. et al.: Investigation of a Melissa officinalis special extract on Cognition I: In vitro study on muscarinic properties. Agro Food Industry Hi Tech. 2015.
• FOSTER M. et al.: Effect of vegetarian diets on zinc status: a systematic review and meta-analysis of studies in humans. J Sci Food Agric. 2013.
• KIM S. et al.: Nutritionally recommended food for semi- to strict vegetarian diets based on large-scale nutrient composition data. Sci Rep. 2018.
• ŚLIWIŃSKA A. et al.: Iron status and dietary iron intake in vegetarians. Adv Clin Exp Med. 2018.
• BAIQ J.A. et al.: Vitamin D status among vegetarians and non-vegetarians. J Ayub Med Coll Abbottabad. 2013.
• LAPPE J.L. et al.: The Role of Vitamin D in Human Health: A Paradigm Shift. Journal of Evidence-Based. 2011.
• MENAL-PUEY et al.: Developing a Food Exchange System for Meal Planning in Vegan Children and Adolescents. Nutrients. 2019.
• PAWLAK R. et al.: How prevalent is vitamin B12 deficiency among vegetarians? Nutrition Reviews. 2013.
• DOMENCINI L. et al.: D-mannose a promising support for acute urinary tract infections in women. A pilot study.: Eur. Rev. Med. Pharmacol. Sci. 2016.
• mcePharma et al.: Neo sleep ODT supplement – Dietary supplement in form of orally dispersible tablet containing highly soluble and bioavailable melatonin. 2017.
• mcePharma et al.: Neo migraine prevention - a dietary supplement for migraine prevention with its own scientific study, in the form of orally dispersible tablets. 2018.
• mcePharma et al.: Neo curcumin supplement - a dietary supplement in the form of orally dissolving tablet (ODT) containing high-bioaccumulation curcumin. 2017.
• mcePharma et al.: Curcumin with high solubility and bioavailability in complementary feed MiniTabs. 2018.
• RITSNER M. S. et al.: L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J. Clin. Psychiatry. 2011.
• SUN Y. Y. et al.: Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular Systém. Phytother. Res. 2017.
• BEJAR E. et al.: Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin. J. Ethnopharmacol. 1996.
• NEILL L. A. et al.: Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: A cytotoxic effect. Br. J. Clin. Pharmacol. 1987.
• KWOK B. H. et al.: The anti-inflammatory natural product parthenolide from the medicinal herb feverfew directly binds to and inhibits IkappaB kinase. Chem. Biol. 2001.
• LOCKYER S. et al.: Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial. Br. J. Nutr. 2015.
• PAQUETTE M. et al.: Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial. Br J Nutr. 2017.
• RAJESH L. et al.: Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J. 2006
• GARCIA-ALLOCA M. et al.: Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J. Neurochem. 2007.
• BANERJEE M. et al.: Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacol. Immunotoxicol. 2003.
• FUNK J. L. et al.: Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J. Nat. Prod. 2006.
• SHING C.M. et al.: Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. Journal of Applied Physiology. 2006.
• ANTONIO J. et al.: The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001.
• SHING C.M. et al.: Bovine Colostrum Supplementation and Exercise Performance. Sports Medicine. 2009.
• CESARONE M.R. et al.: Prevention of Influenza Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects. Clin Appl Thromb Hemost. 2007.
• PAKKANEN R., AALTO J.: Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal. 1997.
• HURLEY, W. L., P. K. THEIL.: Perspectives on Immunoglobulins in Colostrum and Milk. Nutrients. 2011.
• MOSKOWITZ R.W.: Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000.
• JIANG J.X. et al.: Collagen peptides improve knee osteoarthritis in elderly women. Agro Food Industry Hi Tech. 2014.
• BENITO-RUIZ P. et al.: A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr. 2009.
• WILLIAMSON S.M. et al.: Curcumin and resveratrol reduce lipopolysaccharide mediated glycosaminoglycan release in an explant model of canine articular cartilage.: Osteoarthritis Cartilage. 2006.
• MAGGS, DJ. et al.: Efficacy of oral supplementation with L-lysine in cats latently infected with feline herpesvirus.: Am. J. Vet. Res. 2003.
• AK T. et al.: Antioxidant and radical scavenging properties of curcumin.: Chem. Biol. Interact. 2008.: Eur Rev Med Pharmacol Sci. 2018
• GHOSH T. et al.: A review on new generation orodispersible tablets and its future prospective.: Int. J. Pharm. Pharm. Sci. 2011.
• FU Y. et al.: Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies.: Crit Rev Ther Drug Carrier Syst. 2004.
• CARNEVALE G. et al.: Anxiolytic-like effect of Griffonia simplicifolia Baill. seed extract in rats.: Phytomedicine. 2011.
• NAKAZAWA T. et al.: Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice.: J. Pharm. Pharmacol. 2003.
• SONG C.H. et al.: Effects of Theanine on the Release of Brain Alpha Wave in Adult Males.: Korean J. Nutr. 2003.
• LEMOINE P. et al.: Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects.: J Sleep Res. 2007.
• ARENDT J. et al.: Efficacy of Melatonin Treatment in Jet Lag, Shift Work, and Blindness.: J. Biol. Rhythms. 1997.
• HOWELL A.B. et al.: Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis. 2010.
• WANG L. et al.: Bioavailability and bioavailable forms of collagen after oral administration to rats. J Agric Food Chem. 2015.
• BATISSE D. et al.: Influence of age on the wrinkling capacities of skin. Skin Res Technol. 2002
• ASSERIN J. et al.: An oral supplementation based on hydrolyzed collagen and vitamins improves skin elasticity and dermis echogenicity: a clinical placebo-controlled study. J Cosmet Dermatol. 2015.
• ASSERIN J et al.: The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015.
• EFSA: Scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food [AFC] on a request from the commission on selenium-enriched yeast as source for selenium. EFSA J. 2008.
• KIELISZEK M., BŁAŻEJAK S.: Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review. Molecule. 2016.
• KATAGIRI M. et al.: Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr. 2012.
• PARK J.S. et al.: Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010.
• FASSETT R.G. et al.: Astaxanthin: a potential therapeutic agent in cardiovascular disease. Mar Drugs. 2011.
• HUANGFU J. et al.: Antiaging effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress. J Agric Food Chem. 2013.