Stop Migraine

Natural prevention of migraine attacks and severe headache, a unique product combining the effect of feverfew extract and Baical skullcap extract, enriched with selected vitamins.

The only one product on the market with scientifically proven high solubility and cellular absorption of effective plant extracts - up to 300 times higher than that of commonly available products, developed in cooperation with the First Faculty of Medicine of Charles University, Czech Republic.

In a form of orally soluble tablets (ODT) for maximum absorption and convenient use.

 

Product description

  • Effective food supplement with its own scientific study, contributing to long-term prevention of migraine attacks and containing a unique combination of natural active ingredients

  • The product is developed in a cooperation with First Faculty of Medicine, Charles University and its workplace, Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (Biocev) in the Czech Republic

  • It is the only product on market with scientifically proven high cell absorption and solubility of active ingredients - extracts of Tanacetum parthenium (Feverfew) and Scutellaria baicalensis (Baical skullcap)

  • User-Friendly form - tablets dissolve quickly in the mouth (ODT), no water need

  • A unique and innovative solution – tablets release the contained active ingredients directly through the mucous membrane of the oral cavity. Thanks to the advanced formulation approach, the active substances are released and absorbed in the oral cavity and the upper part of the esophagus, thus avoiding the passage of the liver. This results in much higher efficiency even at low doses. If the active ingredients were administered in a classic tablet, a majority of administered dose would be destroyed or converted into ineffective substances through the passage the digestive tract and the liver, thereby reducing the effectiveness of the administered dose.

  • The tablet rapidly (within 40 seconds) releases the main active ingredients of the standardized extract of Feverfew (up to 60% of parthenolides) and Skullcap (up to 85% of baicalin)

  • These extracts and their active substances are formulated to penetrate faster into the human body cells. Parthenolides released from STOP migraine are absorbed through the cell membrane model 300 times more than competing products. Baicaline in up to 1.5 times more than competing products


  • Active substance: a tablet contains 10 mg of baical scullcap extract (up to 85% of baicalin), 10 mg of Feverfew extract (up to 85% of baicalin), 0.6 mg of vitamin B1 and 0.8 mg of vitamin B6

  • Recommended usage: 2 tablets per day (1 tablet in the morning and 1 tablet in the evening) dissolve a tablet in the mouth

  • Packaging: 60 tablets in a container


  • Vegan, No added sugar, No preservatives, No artificial colours and aromas

  • Product is offered as private label or ready-made product

  • Packaging according to customer's requirements

Key Ingredients

Feverfew

Feverfew

Well-known antioxidant that helps the normal functioning of the circulatory system, it has a relaxing and analgesic effect. Its main active ingredients are parthenolides.

Baical scullcap

Baical scullcap

The main active substances of Baical scullcap are mainly flavonoids - baicalein, baicalin, wogonin. Flavonoids also bioflavonoids, or vitamin P, are known for their antioxidant effects.

L-theanin

L-theanin

98% extract of Chinese tea, positively affects the mental state, vitality, performance and concentration.

Vitamins B1 and B6

Vitamins B1 and B6

Vitamins B contribute to the normal functioning of the nervous system and to normal mental activity. Also vitamin B1 contributes to normal function of the heart and normal energy metabolism. Vitamin B6 is necessary for metabolism of proteins and glycogen.

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Summary of our scientific study

Increase absorption of Feverfew and Scullcap

​​​​​​​Summary of our study

In the context of research and development cooperation between mcePharma s.r.o. and First Faculty of Medicine, Charles University and its workplace Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (Biocev), increased solubility and cell absorption of the Feverfew and Skullcap extracts active substances was achieved.

One of the problems associated with administration of the feverfew extract is the lack of solubility of the active substances - parthenolides. It is possible to increase solubility the formation of complexes with a suitable substance. The formation of these complexes is governed by stoichiometric ratios of the active substances, in the case of parthenolides and complexing compounds. Upon subsequent contact with the body fluids, the parthenolides are released from these complexes. In the pharmaceutical industry, inclusion complexes and chelates are widely used. This procedure can also be used to adjust the solubility of parthenolides.

Do not hesitate to contact us for more information on the study!

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Comparison of absorption of partenolides through the model membrane of STOP Migraine and commercial products



Product A

0.7 % 


Product B

13 %


STOP Migraine

100 %


1


In comparison to competitive products A and B, up to 300 times more parthenolides pass-through model membrane in our product STOP Migraine.

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